What causes chronic pain? Poor circulation to ligaments and joints. As we age, this further decreases both circulation and oxygen utilization. Trauma produces localized edema, inflammation, and depolarized membranes causing a further localized decrease in circulation. Decreased circulation from trauma means a  further decrease in oxygen utilization secondary to decreased oxygen and nutrient delivery. Break the cycle of injury by delivering mitochondrial nutrients, anti-inflammatories, and oxygen. Ozone stimulates increased oxygen utilization by forming peroxides which oxidize NADH to NAD. An injured area sends out biochemical messengers that draw in stem cells and other healing cells. These cells will repair the damage if they have what they need. They need adequate oxygen utilization. The same factors that caused the chronic pain in the first place interfere with stem and healing cell growth factor activities.

What is Prolozone?
Prolozone is homeopathic, nutrient, oxygen injection technique. Ozone stimulates circulation. Mitochondrial function is stimulated by the peroxides. The stem cells and healing cells get the nutrients they need and healing occurs. The healing power of oxygen is something every person understands. The therapy use natural healing substances to help promote the body to heal itself.

Helps with:
-       Joint pain
-       Regeneration of cartilage and ligament
-       Chronic neck and back pain
-       Rotator cuff injuries
-       Degenerative discs
-       Plantar fasciitis
-       Carpal tunnel syndrome
-       TMJ
-       Sciatica
-       Neuromas
-       Tennis elbow
-       Sciatica
-       Sinus
-       Infections
-       Pelvic disorders
-       Dental infections
-       Scars
-       Pelvic floor syndrome

1.     Bahrami, M. H., Raeissadat, S. A., Nezamabadi,M., Hojjati, F., & Rahimi-Dehgolan, S. (2019). Interesting Effectiveness of Ozone Injection for Carpal Tunnel Syndrome Treatment: A Randomized Controlled Trial.Orthop Res Rev, 11, 61–67. DOI: 10.2147/ORR.S202780
2.     Hashemi, M., et al. (2015). The Effects of Prolotherapy With Hypertonic Dextrose Versus Prolozone (Intraarticular Ozone) in Patients With Knee Osteoarthritis. Anesth Pain Med, 5(5), e27585. DOI: 10.5812/aapm.27585
3.     Raeissadat, S. A., Tabibian, E., Rayegani, S. M., Rahimi-Dehgolan, S., & Babaei-Ghazani, A. (2018). An Investigation into the Efficacy of Intra-articular Ozone (O2–O3) Injection in Patients with Knee Osteoarthritis: A Systematic Review and Meta-analysis. J Pain Res, 11, 2537–2550. DOI: 10.2147/JPR.S175441
4.     Seyam, O., et al. (2018). Clinical Utility of Ozone Therapy for Musculoskeletal Disorders. Med Gas Res, 8(3), 103–110. DOI: 10.4103/2045-9912.241075
5.     Smith, N. L., Wilson, A. L., Gandhi, J., Vatsia, S., & Khan, S. A. (2017). Ozone Therapy: An Overview of Pharmacodynamics, Current Research, and Clinical Utility. Med Gas Res, 7(3), 212–219. DOI: 10.4103/2045-9912.215752
6.     Wang, X., Wang, G., Liu, C., & Cai, D. (2018). Effectiveness of Intra-articular Ozone Injections on Outcomes of Post-arthroscopic Surgery for Knee Osteoarthritis. Exp Ther Med, 15(6): 5323–5329. DOI: 10.3892/etm.2018.6101