Thymosin Beta 4

This wonderful peptide has a multitude of uses. It is found in almost all cells. It most notably is seen to increase healing in all areas of the body. Thymosin Beta 4 (TB4) has been found to be useful in dry eye and corneal wound healing disorders (Sonse). It has been found useful in increasing the number of cells that are involved in healing. It also can be found to help these cells move to the area that has been injured. TB4 is anti-inflammatory. It helps promote new blood vessel growth, which can aid in healing. It helps lay down more collagen. It can protect cells against harmful agents that enter the body (Sandersm).

Some areas thymosin beta 4 may help:
-       dry eye
-       corneal wound healing disorders
-       fatty liver disease
-       hair growth
-       general repair
-       cardiac protection
-       neuroprotective
-       antimicrobial
-       decreases scar tissue formation
-       improves T cells
-       stem cell maturation
-       Soft Tissue Repair – tendon, ligament, muscle
-       Sports/athletic injuries
-       Pressure or venous stasis ulcers
-       Conditions requiring immune response modulation
-       Brain issues if autoimmunity suspected
-       Ischemic stroke
-       Traumatic brain injury (TBI)
-       Concussion

1.     Gao, X., et al. (2016). Role of Thymosin Beta 4 in Hair Growth. Mol Genet Genomics, 291(4), 1639-46.  DOI: 10.1007/s00438-016-1207-y
2.     Goldstein, A. L, Hannappei, E, Sosne, G., & Kleinman, H. K.. (2012). Thymosin Beta4: A Multifunctional Regenerative Peptide: Basic Properties and Clinical Applications. Expert Opin Biol Ther, 12(1), 37-51. DOI: 10.1517/14712598.2012.634793
3.     Jiang, Y, et al. (2017). Potential Role of Thymosin Beta 4 in the Treatment of Nonalcoholic Fatty Liver Disease. Chron Dis Trans Med, 3(3), 165-68. DOI: 10.1016/j.cdtm.2017.06.003
4.     Kleinman, H. K., & Sosne, G. (2016). Thymosin β4 Promotes Dermal Healing. Vitam Horm, 102, 251-75. DOI: 10.1016/bs.vh.2016.04.005
5.     Sosne. G. (2018). Thymosin Beta 4 and the Eye: The Journey From Bench to Bedside. Expert Opin Biol Ther, 18(sup1), 99-104. DOI: 10.1080/14712598.2018.1486818
6.     Sandersm M. C, Goldstein, A. L, Wang, Y. (1992). Thymosin B4 (Fx peptide) is a potent regulator of actin polymerization in living cells. Proc Natl Acad Sci USA. 89, 4678-4682. DOI: 10.1073/pnas.89.10.4678
7.     Shrivastava, S., Srivastava, D., Olson, E. N, DiMaio, J. M., & Bock-Marquette, I. (2010). Thymosin Beta4 and Cardiac Repair. Ann NY Acad Sci, 1194:87-96. DOI: 10.1111/j.1749-6632.2010.05468.x
8.     Yarmola, E. G, Kilmenko, E. S, Fujita G, & Bubb, M. R. (2007). Thymosin Beta4: Actin Regulation and More. Ann NY Acad Sci, 1112, 76-85. DOI: 10.1196/annals.1415.008